The effect of hydrogen-rich saline on the brain of rats with transient ischemia.
In rats, compared with rats with I/R only, hydrogen-rich saline treatment significantly improved the amount of surviving cells. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.
In mice, infarct zone and area with loss of tissue structure and marked cellular infiltration were significantly decreased in groups treated by hydrogen gas inhalation during ischemia-reperfusion; however, these effects were not observed by posttreatment of hydrogen. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreAlleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes.
After a single postexercise intervention, the H₂ group showed improved antioxidant capacity and reduced WBC and CRP levels. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreEffects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases
This narrative review examined there are gaps in the knowledge about the role molecular hydrogen plays, in the treatment of metabolic diseases and other NCDs This review aims to discuss the role of hydrogen in the pathogenesis and prevention of NCDs. Western diet and lifestyle, which are major risk factors of NCDs, are known to cause oxidative stress and decrease in production of molecular hydrogen in the intestines which leads to a decline in endogenous antioxidant status in the body, leading to increase in systemic inflammation. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMicro/Nanomaterials-Augmented Hydrogen Therapy.
This narrative review examined the available molecular-hydrogen literature. In this review, various strategies of micro/nanomaterials-augmented hydrogen therapy, including micro/nanomaterials-mediated targeted hydrogen delivery, controlled hydrogen release, and nanocatalytic and multimodel enhancement of hydrogen therapy efficacy, are summarized, which can open a new window for treatment of inflammation-related diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment.
This narrative review examined the available molecular-hydrogen literature. H₂ regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMolecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.
This narrative review examined the available molecular-hydrogen literature. Molecular hydrogen therapy is able to significantly reduce the release of inflammatory factors and oxidative stress injury. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMolecular hydrogen: An inert gas turns clinically effective.
This narrative review examined the available molecular-hydrogen literature. The present paper overviews the clinical relevance of molecular hydrogen, and summarizes data from clinical trials on this innovative medical agent. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreAccurate in vivo real-time determination of the hydrogen concentration in different tissues of mice after hydrogen inhalation.
In mice, the H₂ saturation concentrations varied among tissues significantly regardless of the concentration of H₂ inhaled, and they were detected the highest in the kidney but the lowest in the gastrocnemius. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreElectrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.
In participants with chronic HD were enrolled and received ERW administration for 6 month, hD resulted in decreased plasma VC, total antioxidant status, and erythrocyte metHb/ferricyanide reductase activity and increased erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and plasma metHb. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
Read MoreEffectiveness of oral and topical hydrogen for sports-related soft tissue injuries.
In 2013 participants, oral and topical hydrogen intervention was found to augment plasma viscosity decrease as compared with the control group (P = 0.04). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
Read MoreMolecular hydrogen for outpatients with Covid-19 (Hydro-Covid): a phase 3, randomised, triple-blinded, adaptive, placebo-controlled, multicentre trial
In 2 patients, due to its antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties, molecular hydrogen (H₂ ) is potentially a novel therapeutic gas for acute coronavirus disease 2019 (COVID-19) patients. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreMolecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.
This narrative review examined the available molecular-hydrogen literature. Molecular hydrogen (H₂) was believed to be inert and nonfunctional in mammalian cells. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreROS-scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis.
In a complete Freund's Adjuvant-induced RA mouse model, this controlled hydrogen release behavior significantly downregulated pro-inflammatory mediators, protecting chondrocytes from apoptosis and preventing cartilage degradation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application.
This narrative review examined the available molecular-hydrogen literature. Due to its high bioavailability, H₂ is considered a therapeutic gas for the treatment of various diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
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