Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.
This animal study examined Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation; reported duration 42 days. The abstract reports: Hydrogen inhalation (75%) ameliorated SCI in vivo and attenuated neuronal mechanical injuries in vitro, and its protective effect on spinal cord neurons was exerted…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.
This uncontrolled human study examined Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. The abstract describes Human participants. The abstract reports: The results of MTT indicated that H2 and RAP could increase cell viability after OGD/R treatment, while 3-MA further aggravated injury and inhibited the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreOpen-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.
This randomized controlled trial examined Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. The abstract describes Human participants; sample size 10; reported duration 12 weeks. The abstract reports: Hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM. Less prominent effects with the double-blind trial compared to the open-label trial…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
This animal study examined Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species. The abstract describes Mouse model. The abstract reports: Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas post‑conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway
This animal study examined Hydrogen gas post‑conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway. The abstract describes Rat model. The abstract reports: Therefore, these observations suggest that post-conditioning with hydrogen gas ameliorated SAH-induced neuronal pyroptosis at least in part through the mitoK/ERK1/2/p38 MAPK signaling pathway. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway.
This uncontrolled human study examined Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This animal study examined Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. The abstract describes Mouse model. The abstract reports: The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression.
This uncontrolled human study examined Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression. The abstract describes Human participants. The abstract reports: Hydrogen improved cell injury and mitochondrial quality, which were associated with HO-1 expression promoted by the Nrf2/YY1 complex in vitro. Thus, hydrogen treatment may…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHigh-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics.
This animal study examined High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of high concentration (67%) of H in septic mice improved the survival rate and reduced neuronal injury. Its mechanism might be mediated by…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEvaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.
This case report or case series examined Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study. The abstract describes Human participants. The abstract reports: This study is the first human clinical trial evaluating HRCC capsules in patients with metabolic syndrome. Based on the safety and potential TG-lowering effects…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials
This meta-analysis examined The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. The abstract describes Published literature review; hydrogen delivered as hydrogen water. The abstract reports: RESULTS: Twelve articles comprising 13 RCTs (n = 757 participants) were included. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.
This animal study examined Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics. The abstract describes Mouse model. The abstract reports: Therapy with 2% H increased PaO/FiO ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells
This animal study examined Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells. The abstract describes Mouse model. The abstract reports: Our prospective observational study revealed that maternal production of H is significantly lower in pregnant women with PTB, suggesting its potential as a biomarker…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreChronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats.
This uncontrolled human study examined Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline; reported duration 3 months. The abstract reports: Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction.
This in vitro or cellular study examined Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction. The abstract describes Cell culture / in vitro model. The abstract reports: As a result, H protected the cultured cells against the cytotoxic effects induced by -butyl hydroperoxide; H suppressed cellular fatty acid peroxidation and cell…. This is an automated editorial draft based on the abstract and requires source review before publication.
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