Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In a laboratory model, thus, the anti-angiogenic activity of PT2385 (HIF-2α inhibitor) was potentiated by H₂ and silncARSR significantly. The authors concluded that looking forward to future clinical translation, the therapeutic efficacy of this approach could be further enhanced through integration with…
Read ArticleIn rats, western blot analysis showed decreased NLRP3, ASC, caspase-1, MMP-2/9, TLR4 and Bax protein levels after hydrogen-rich saline treatment, while Bcl-2 expression increased after hydrogen-rich saline treatment.…
Read ArticleIn rats, the VSD + H₂ group demonstrated superior efficacy in reducing serum inflammatory markers compared to the VSD group (Figure 1F ), with significantly lower malondialdehyde (MDA)…
Read ArticleThis narrative review examined to synthesize experimental and clinical evidence on mitochondria-targeted strategies in acute pancreatitis (AP) and evaluate the potential of interventions that preserve or restore mitochondrial…
Read ArticleThis systematic review examined dietary supplements might have reciprocal and multilevel interactions with mitochondria network; however, no systematic review assessed the role of different nutraceuticals in mitochondria modification…
Read ArticleMolecular hydrogen is a selective antioxidant with anti-inflammatory, cytoprotective, and signal-modulatory properties. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes…
Read ArticleIn mice, 3 3.1 Mice were injected intraperitoneally with LPS, and the effects of CCH administration and 4% hydrogen inhalation were observed. These preclinical findings add evidence supporting…
Read ArticleThis narrative review examined the efficacy and potential clinical applications of antioxidant therapies in RA, emphasizing their role in mitigating oxidative damage and improving treatment outcomes. Oxidative stress…
Read ArticleIn participants, preclinical and small-scale clinical studies suggest potential benefits of NRF2 activation, high-dose thiamine, CoQ10, molecular hydrogen, and oxygen-ozone (O2O3) therapy. These findings add human evidence supporting…
Read ArticleThese findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read ArticleThe results demonstrated that H₂ alleviated CIH-induced vascular endothelial aging by improving the pathological injury of the aorta, alleviating vasodilation dysfunction, decreasing the expression of oxidative stress and…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. This ultimately leads to impaired cardiac contractility and reduced cardiac output, with a 5-year HF-associated mortality rate up to 75%.…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Sepsis-associated encephalopathy (SAE) is a devastating neurological complication of sepsis, leading to diffuse brain dysfunction, long-term cognitive deficits, and increased…
Read ArticleIn ATG9B was knocked down using siRNA in vitro and AAV-shRNA in the hippocampal CA1 region in vivo to clarify its function, H₂ inhalation increased 7-day survival in…
Read ArticleThis narrative review examined by placing NO, H2S, and H₂ into one comparative redox framework, this review aims to clarify what is established, what remains inferential, and where…
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