Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In rats, histological analysis revealed a marked reduction of interstitial congestion, edema, inflammation, and hemorrhage in renal tissue harvested 24 h after HRSS treatment compared to saline administration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…
Read ArticleIn dogs, among all groups, NAD content and the number of apoptotic and 8-OHdG positive cells was not significantly different, indicating that the cardioprotection afforded by H(2) was…
Read ArticleIn a laboratory model, H₂ suppressed the expression of HIF1α and PDK1, suggesting that H₂ may act upstream of hypoxia-driven signaling pathways. The authors concluded that the findings…
Read ArticleIn cancer cells, the asymmetric PAA-AB@PDA NPs selectively scavenge cytotoxic ·OH, thereby disrupting the redox homeostasis, which in turn leads to mitochondrial damage and reduced ATP production. These…
Read ArticleIn mice, rOS fluorescence staining and flow cytometry showed that HNBs significantly reduced Dox-induced ROS increases. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleThis narrative review examined nevertheless, this narrative review provides a novel theoretical framework integrating hydrogen with the mast cell‐sleep‐wake rhythm‐melatonin axis, identifies shared pathological targets (oxidative stress, mitochondrial…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The biological effects of molecular hydrogen are moving beyond the traditional explanatory framework of "selective antioxidation." This article systematically integrates…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read ArticleThe researchers observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH2 treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn a laboratory model, hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. The authors concluded that preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory…
Read ArticleIn SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. The authors linked these…
Read ArticleIn mice, intermittent hypoxia significantly increased plasma levels of low- and very low-density cholesterol and the amount of 4-hydroxy-2-nonenal-modified protein adducts in the LV myocardium. These preclinical findings…
Read ArticleIn mice, compared with WT-H₂ mice, 5xFAD-Veh mice exhibited increased BAX expression ( p < 0.05) and reduced BCL-2 expression, whereas H₂ treatment in 5xFAD-H₂ mice decreased BAX,…
Read ArticleIn mice, this study showed that administration of H₂-rich saline by peritoneal injection (6 mL/kg/24 h) improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and…
Read ArticleIn participants, there is also a reduction in cerebral blood flow, leading to hypoxia and reduced removal of metabolic waste, which further exacerbates the injury. These findings add…
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