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In mice, compared with sepsis group, neurological function significantly improved and damaged neurons in hippocampal CA1 region significantly reduced. The activities of SOD and CAT markedly increased and the levels of MDA and 8-iso-PGF2α markedly decreased in sera and hippocampus; the time…
Read ArticleIn mice, the daily administration of HRW also progressively reduced the thermal allodynia induced by PTX injection ( p < 0.001; one-way ANOVA, against vehicle plus vehicle-treated animals;…
Read ArticleIn an animal model, ninety-six hours survival rates were significantly higher in the H₂ (80.0%) and H₂+TH (90.0%) groups than TH (30.0%) and to Ctrl (30.0%). These preclinical…
Read ArticleSerum cardiac troponin T and S100B measured during earlier post-resuscitation period were markedly reduced in both H₂ inhalation and hypothermic groups. These results are preclinical and suggest molecular…
Read ArticleIn male Sprague-Dawley rats, h(2)-rich saline treatment improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats. These preclinical findings add evidence…
Read ArticleIn mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These results are preclinical and suggest molecular hydrogen's therapeutic potential in…
Read ArticleThe researchers found that the expression of LC3 was increased after OGD/R which can be further enhanced by H₂ and RAP treatment, but treatment with 3-MA was opposite.…
Read ArticleIn C57BL/6 mice, western blot analysis showed that coadministration of 1.3% hydrogen gas significantly (P < 0.001) reduced the level of neuronal apoptosis to approximately 40% compared with…
Read ArticleIn 429 patients with a 90-day Cerebral Performance Category (CPC) of 1 or 2 assessed in a full-analysis set, the Cox proportional hazards model showed a lower adjusted…
Read ArticleIn rats, at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content,…
Read ArticleIn 72 patients, however, hydrogen + TTM32-TTM34 did not improve survival compared with TTM32-TTM34 alone (adjusted hazard ratio: 0.22 [95% CI, 0.05-1.06], p = 0.06). These findings add…
Read ArticleThe researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis…
Read ArticleThis publication examined hydrogen gas using the study design reported by the authoritative source. No study results are reported because this publication is a protocol.
Read ArticleIn rats, neuronal degeneration and microglial activation in a vulnerable brain region was suppressed by both TTM alone and H₂ inhalation alone, with the combined therapy of TTM…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. This review synthesises the current evidence on H₂ therapy in SAE and highlights key directions for future research, focusing on…
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