Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In rats, hydrogen-rich medium attenuated the intracellular production of ROS (especially HO•), astrogliosis, and the secretion of proinflammatory cytokines in astrocytes 12 h after H₂O₂-induced injury. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleIn mice, this article demonstrated that administration of hydrogen-rich saline increased survival rate of cGVHD mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Molecular hydrogen (H₂), administered primarily as hydrogen-rich water (HRW), has emerged as a potential therapeutic candidate due to its selective…
Read ArticleIn 5 patients, HRW was not superior to placebo in preventing clinical worsening at day 14: in the H₂ group, 46.1% in the H₂ group, 43.5% in the…
Read ArticleIn mice, immunohistochemical staining for the oxidative stress marker, 4-hydroxy-2-nonenal and 8-hydroxydeoxyguanosine, showed that hydrogen administration suppressed oxidative stress induced by ligation in the spinal cord and the…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such…
Read ArticleIn an animal model, hydrogen improved the deteriorated hypertrophic responses and inhibited the enhanced autophagic activity mediated by ISO administration in vivo, as indicated by decreasing HW and…
Read ArticleIn mice, and, the hydrogen-rich gases pretreatment improved the Hsp60 protein expression in pancreatic tissues of AP mice at 1 h and 5 h. These preclinical findings add…
Read ArticleIn mice, the activation of NLRP3 inflammasome in AP mice was substantially inhibited following the administration of hydrogen-rich saline, which was paralleled with the decreased NF-κB activity and…
Read ArticleIn Sprague-Dawley rats, hydrogen-rich saline treatment significantly attenuated the severity of l-Arg-induced AP by ameliorating the increased serum amylase activity, inhibiting neutrophil infiltration, lipid oxidation and pancreatic tissue…
Read ArticleIn Following reperfusion, segments of terminal jejunum were rapidly taken and transferred into isolated organ bath and responses to KCl were recorded, hydrogen-rich saline treatment significantly attenuated the…
Read ArticleIn rats, malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment. These preclinical findings…
Read ArticleIn rats, compared to MNU-treated rats, retinal malondialdehyde (MDA) content in MNU + hydrogen-rich saline rats significantly decreased while superoxide dismutase (SOD) activity significantly increased. These preclinical findings…
Read ArticleIn vitro studies also confirmed the anti-proliferative capability of the hydrogen solution and ROS generation in VSMCs induced by PDGF-BB. The authors concluded that hRSS may have a…
Read ArticleIn rats, it was found that systemic HRW treatment slightly suppressed autophagy and then activated the Keap1-Nrf2 signaling pathway by maintaining the Keap1-Nrf2-P62 interaction and improved the osteoporotic…
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