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In male Sprague-Dawley rats, hydrogen-rich saline attenuates BDL-induced liver damage, possibly by the reduction of inflammation and oxidative stress and the inhibition of the ERK1/2 pathway. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleIn What's more, HHW ameliorated lipid accumulation by regulating miR-136/MEG3/Nrf2 axis in vitro and in vivo, miR-136 was downregulated, MEG3 as well as Nrf2 was upregulated and serum…
Read ArticleIn rats, hydrogen enriched saline treatment significantly attenuated the severity of liver injury induced by ischemia-reperfusion. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the…
Read ArticleIn an animal model, hS significantly increased hydrogen concentration in liver and kidney tissues. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…
Read ArticleIn an animal model, however, ALT and AST activity significantly decreased at T3h and T1d and AKP activity significantly decreased at T1d in the IRI + hydrogen-rich saline…
Read ArticleThis publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
Read ArticleIn rats, hydrogen gas reduced hepatic reperfusion injury after prolonged cold preservation via the maintenance of portal flow, by protecting mitochondrial function during the early phase of reperfusion,…
Read ArticleIn C57BL/6 mice, culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it…
Read ArticleThe researchers found that saturated hydrogen saline treatment efficiently decreased the activation of ERK and JNK, while promoting the activation of p38 (P<0.05 compared with LPS), suggesting the…
Read ArticleIn rats, no significant differences in dissolved H₂ or ORP values were observed in the HRW samples either at 4 °C or at 25 °C within 24 h.…
Read ArticleIn rats, the mechanism of this phenomenon suggests that H₂ may have effectively attenuated AOC‐induced inflammatory and oxidative damage, and decreased matrix metalloproteinase activity. These preclinical findings add…
Read ArticleIn rats, the hydrogen-rich UW solution group also showed less oxidative damage and hepatocyte apoptosis than the control group, and the expression of proinflammatory cytokines tended to be…
Read ArticleIn mice, the HW group showed a smaller decrease in hepatic cholesterol; however, stronger antioxidative effects in serum and lower peroxisome proliferator-activated receptor-α expression in the liver were…
Read ArticleIn an animal model, liver samples in the group with inhaled hydrogen showed a statistically significant reduction in histological changes compared to the control group. These preclinical findings…
Read ArticleIn an animal model, apoptosis in cholangiocytes isolated from a rat model of liver ischemia/reperfusion injury indicated that H₂ significantly attenuates ischemia/reperfusion cholangiocyte injury in vivo. These preclinical…
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