Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions, meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway. The…
Read ArticleIn guinea pigs, hRS reduced the ROS and MDA levels and increased SOD level in guinea pigs of AR-HRS group accompanied with decreased frequency of sneezing and scratches.…
Read ArticleThe researchers found that the beneficial effects of H₂ treatment on ZY-induced organ damage were associated with the decreased levels of oxidative product, increased activities of antioxidant enzyme,…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The authors highlighted early evidence of cytoprotective, antioxidant, and anti-inflammatory effects. The reviewed evidence adds support for molecular hydrogen's therapeutic…
Read ArticleIn rats, H₂ improved HO-1 mRNA and protein expression and activities in the process of pain. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn a laboratory model, hydrogen gas can reduce cytotoxic reactive oxygen species (ROS) that are produced in inflamed tissues. The authors concluded that experimental results indicate that the…
Read ArticleIn mice, repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice, assessed by tail suspension…
Read ArticleIn The researchers previously showed that H₂ acts as a novel antioxidant to protect cells against oxidative stress, exposure of cultured cells to the H₂-dependently autoxidized phospholipid species…
Read ArticleIn mice, the inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to 70 or 60%, respectively. These preclinical…
Read ArticleIn mice, at day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta…
Read ArticleIn a laboratory model, H₂ treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-α, IL-1β, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3…
Read ArticleThe researchers found that resuscitation by hydrogen-rich saline alleviated inflammation significantly. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured…
Read ArticleThe researchers found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice. The authors concluded that the authors' studies also suggest that hydrogen is…
Read ArticleIn mice, 3.3 Immunoblot analysis of the tibialis cranialis muscle showed that Nrf2 protein expression was significantly lower in the HRW group than in the PW group, both…
Read ArticleIn This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery, hydrogen exposure significantly reduced collagen (p = 0.01), TRAP-6 (p =…
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