A novel method of preserving cardiac grafts using a hydrogen-rich water bath.
In rats, myocardial injury and inflammatory events were significantly attenuated by organ storage in the hydrogen-rich water bath. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreConsumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
In mice, kEY FINDINGS: H2W consumption significantly attenuated plaque formation and enhanced plaque stability in ApoE-/- mice, accompanied by altered gut microbiota structure and short-chain fatty acid profiles. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of hydrogen as adjuvant treatment for unstable angina.
In The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo, serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment. The authors concluded that an atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreEffect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
In rats, compared with the ischemic period, the ischemia-reperfusion phase showed significantly increased SOD activity and significantly decreased MDA content in the hydrogen-rich water group, while SOD activity was significantly decreased, and MDA content was significantly increased in the control group (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury.
In Wistar rats, 25 proteins that are involved in hydrogen-water reducing MIRI were selected by high-throughput GSR-CAA-67. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreA New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
This narrative review examined the available molecular-hydrogen literature. Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich water. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
In male Wistar rats, hW intake may prevent lipid deposition in the rat aorta induced by periodontitis by decreasing serum ox-LDL levels and aortic oxidative stress. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreAttenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
In male Wistar rats, the apoptosis rate was significantly decreased in the hydrogen-rich water group, as well. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
Hydrogen-rich medium reduced TCDD-associated senescence changes in human endothelial cells and was accompanied by Nrf2 activation. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreHydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-γ, hydrogen treatment was also associated with increased graft ATP levels and increased activity of the enzymes in mitochondrial respiratory chain. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreAdministration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.
In mice, the numbers of endothelial cells in the atheroma expressing the senescence factors p16INK4a and p21 decreased in HFD-fed mice given HW compared with HFD-fed mice given control water. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases.
This narrative review examined the available molecular-hydrogen literature. This article highlights the dual role of diet in generating molecular hydrogen ( H₂ ) in the gut, and H₂ 's subsequent influence on the pathophysiology and prevention of CVD and T2DM. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.
This narrative review examined the available molecular-hydrogen literature. In this review, evidence of the potential benefits of hydrogen molecules obtained from in vitro, in vivo, and clinical investigations are comprehensively summarized and discussed with a focus on the cardiovascular aspects. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreShort-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.
Drinking HRW increased the maximum power and average power of the 30 s rowing test and decreased the maximum heart rate during the period. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreThe Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification.
In rats, continuous use of H₂-rich water was safe and improved QOL.The incidence and average number of cholangiofibrosis in the liver were higher in the TAA group (100%, 12.0 ± 10.07) than that in the H₂ group (57.1%, 2.86 ± 5.43). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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