The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats.
In male Wistar rats, the study results indicated no significant differences between the administration of HW and metformin. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreThe protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.
In an animal model, drinking HW suppressed the increase in glucose, total cholesterol, oxidative stress, and inflammation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.
Hydrogen-rich water prepared by AC-electrolysis may be effective in improving diverse diabetes-related markers and systemic DNA oxidative injuries through the formation of abundant heat-resistant nanobubbles and the increased hydrogen concentrations. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreSupplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
In 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT, hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.
Read MoreEffectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
In 20 participants with potential metabolic syndrome, further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4., drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome.
Read MoreHydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.
Cg-Leprcp/NDmcr rats treated with HRW showed a 34% decrease in ROS production. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreEffects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model.
In rats, the present findings suggest that HRW conferred significant benefits against abnormalities in the metabolic syndrome model rats, at least by preventing and ameliorating glomerulosclerosis and creatinine clearance. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.
In 0 patients with potential metabolic syndrome, serum analysis showed that consumption of H₂-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. This small study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.
Read MoreEffect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
In an animal model, superoxide dismutase and glutathione levels in liver and heart were significantly higher in DMMH group after hydrogen-rich water treatment. Malondialdehyde and oxidized glutathione levels were decreased in DMMHR group when compared with DMMH group, which indicates that hydrogen-rich water could reduce oxidative stress. qPCR analysis demonstrated that that pro-apoptotic genes Bax/Caspase-3 were upregulated in DM group and metformin treatment suppressed their upregulation (DMM group). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreElectrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial.
In 50 patients with T2DM, however, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreOral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice.
In mice, rBF changes improved significantly in the HRW group compared with the control group from eight weeks of age and persisted throughout the study. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study.
In participants with IFG were enrolled in a randomized, H₂ slightly improved metabolic abnormalities and gut microbiota dysbiosis, providing a novel target and theoretical basis for the prevention and treatment of blood glucose regulation in patients with IFG. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence glucose regulation and metabolic health.
Read MoreOral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.
This narrative review examined the basic research and clinical applications of HRW consumption to support its use for daily health and clinical treatment. Clinically, HRW has been used for adjuvant treatment, disease prevention, and quality of life improvement. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen rich water in oral pathology: an update.
In an animal model, hydrogen-rich water used for prevention or treatment of oxidative stress-related diseases in oral cavity 3: The study was conducted to investigate protective effects of hydrogen-rich water against reactive oxygen species induced cellular harmful events and cell death in human gingival fibroblasts and three-dimensional gingival tissue equivalents. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreDrinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
In 13 patients with periodontitis were divided into two groups: The control group (n = 6) or the HW group (n = 7), a reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
Read MoreBlog Categories
Recent Posts
October 21, 2020
November 16, 2020
October 02, 2017