Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.
In For human ex vivo studies, the researchers collected blood samples from six healthy humans and added normal saline or hydrogen-rich saline to blood and platelet-rich plasma, collagen-induced platelet aggregation was significantly decreased in H₂ gas and HS group rats (p=0.042, 0.018, respectively), while there was no difference in non-H₂ gas and NS group rats before and after treatment. The authors concluded that in summary, these data suggest that hydrogen may inhibit collagen-induced platelet aggregation. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.
In a laboratory model, pro-inflammatory factors and CD16/32 in M1 macrophages were decreased, and the expression of CD16/32 in lamina propria were inhibited after treatment with hydrogen, but the changes has no effects in other tissues. The authors concluded that hydrogen could attenuate the severity of NEC through promoting M1 macrophages conversion by inhibited the expression of NF-κB p65 in the nucleus. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreTwo-Dimensional Mg2 Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin.
In a laboratory model, mechanistically, a sustained supply of hydrogen molecules induces anti-inflammatory M2 macrophage polarization in time by enhancing CCL2 (chemokine C-C motif ligand 2) expression to promote angiogenesis and reduce fibrosis and also enhances the proliferation and migration capability of skin cells directly and indirectly by locally scavenging overexpressed reactive oxygen species, synergistically favoring wound repair. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreElectrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro.
ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors, electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H₂ and the presence of platinum nanoparticles with antioxidant effects. The authors concluded that these results suggest a potential beneficial role of ERW in inhibiting cancer cells growth. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats.
In a laboratory model, hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. The authors concluded that preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory changes, promoted mitochondrial biogenesis in the lungs throughout the procedure, and resulted in better posttransplant graft function. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MorepH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.
In The characterization, toxicity, and pH-responsive H₂ release of AB@HPDA was detected in vitro, hPDA and AB@HPDA significantly inhibited IDD, as tested by X-ray, MRI, disc water content, and histology (P < 0.05). pH-responsive H₂ delivery through AB@HPDAs has the potential to efficiently treat IDD by inhibiting ECM degradation and rebalancing oxidative stress and inflammation in degenerative IVDs. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreNIR-Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy.
In a laboratory model, under NIR irradiation, CNCP heterojunctions exhibit superior photothermal performance and photocatalytic production of reactive oxygen species and hydrogen. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMicrobial hydrogen “manufactory” for enhanced gas therapy and self-activated immunotherapy via reduced immune escape.
In a laboratory model, more interestingly, the researchers found that hydrogen therapy induced by the authors' live PSB did not lead to the up-regulation of PD-L1 after stimulating the immune response, which could avoid the tumor immune escape. These findings from a laboratory model add evidence about molecular hydrogen's biological effects in the model studied.
Read MoreA systematic study on electrolytic production of hydrogen gas by using graphite as electrode
In a laboratory model, from the figure, it was observed that initially the hydrogen production was reached to maximum of 800 cc/min and thereby decreased to attain the stable state. The authors concluded that from the results, the researchers concluded that the high electrolytic concentration (above 0.025 M) is not beneficial for long time hydrogen production without destruction of graphite electrode. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreRadioprotective effect of hydrogen in cultured cells and mice.
In It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro, this paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo. The authors concluded that it is suggested that hydrogen has a potential as an effective and safe radioprotective agent. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreNanoquadruplex-driven hydrogen therapy: NIR-controlled release for targeted cancer ferroptosis.
In The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro, high-efficiency hydrogen can be released from (PdH0.2)4Se, activated by near infrared irradiation (NIR), and combines with available selenium (Se) to produce highly toxic hydrogen selenide (H2Se), which in turn unbalances the GSH/GSSG ratio and induces ROS overproduction. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreElectrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation.
In In the two-stage cell transformation theory, cancer cells first receive initiation, which is mainly caused by DNA damage, and then promotion, which enhances transformation, electrolyzed reduced water (ERW), which is produced near a cathode during electrolysis of water, is an alkaline drinking water that is beneficial to health. The authors concluded that eRW supplemented with Pt nps suppressed transformation at the promoter stage, not at initiation, suggesting that ERW supplemented with Pt nps suppressed the PMA-induced augmentation of intracellular ROS. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMolecular hydrogen enhances osteogenesis in Danio rerio embryos.
In zebrafish embryo, hydrogen-rich water (HRW) does not affect vitality or growth rate up to 15%. The authors concluded that, the researchers demonstrated the beneficial effects of hydrogen on anabolic bone functions in vivo. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
In a laboratory model, the subsequent in vitro experiments showed that H₂ treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-κB and the expression of tumor necrosis factor α and interleukin-1β, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus. The authors concluded that, H₂ treatment can ameliorate the inflammatory response and reduce the expression of inflammatory mediators during the early phase of AP by inhibiting the MAPK pathways and increasing Hsc70 expression. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMolecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
In a laboratory model, molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating endothelial cells; the most pronounced effect was observed after repeated inhalations on day 14 after chronic heart failure modeling. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
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