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In rats, through transmission electron microscopy, the researchers observed that the GSDMD membrane pores in AMs were increased at 12 and 24 h post-burn compared with sham rats; however, hydrogen treatment mitigated this trend ( Figure 6 ). These preclinical findings add…
Read ArticleThe researchers observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH2 treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleThe researchers found that H₂-O₂ mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac…
Read ArticleIn an animal model, regarding the neurological score, the piglets in the TH-H₂ group consistently had the highest score from day 2 to 5 and showed a significantly…
Read ArticleIn an animal model, the released hydrogen gas can effectively regulate redox homeostasis and mitigate excessive inflammation, and the silicic acid can promote the proliferation of reparative cells…
Read ArticleIn rats, pEG led to a significant increase in exhaled H₂ (35 ppm [10-73] compared with control 7 ppm [2-15]; p = 0.001). These preclinical findings add evidence…
Read ArticleIn guinea pigs, the ABR thresholds at 2 and 4 kHz were significantly better on post-noise days 1, 3, and 14 in hydrogen-treated animals when compared to the…
Read ArticleIn guinea pigs, the ABR thresholds measured immediately after the simultaneous exposure to noise and carbon monoxide significantly increased at all frequencies in group 1 while in group…
Read ArticleIn rats, these results suggest the possibility that this drinking water shows an effect in reduction of oxidative stress in the body. These preclinical findings add evidence supporting…
Read ArticleIn an animal model, when the animals were treated with hydrogen-rich water, cochlear damage was significantly reduced: the increase in ABR threshold was 11.7±2.6dB at 8kHz and the…
Read ArticleIn rats, these findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen. These preclinical findings add…
Read ArticleIn an animal model, H₂ treatment essentially prevented the increases in COX-2-immunopositive neurons. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological…
Read ArticleIn an animal model, H₂ was neuroprotective shown both by the enhanced recovery of EEG and by the significant preservation of neurons in the cerebral cortex, hippocampus, basal…
Read ArticleIn mice, this study indicates that hydrogen helps to ameliorate S. aureus-induced mastitis in mice through attenuating TLR2 and Nod2 mediated NF-κB and MAPK activation. These preclinical findings…
Read ArticleIn rats, mDA concentration significantly increased in P15 group compared with C group at 2 h and 6 h, while its concentration is significantly reduced in the H₂…
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