Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In male Wistar rats, hypothesized that inhaled H₂ decreases LPS-induced hippocampal pro-inflammatory cytokines surges and this effect is associated with reduced memory loss. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this…
Read ArticleIn mice, the survival rate, visual and spatial learning ability, and memory ability were improved in septic mice treated with H₂. These results are preclinical and suggest molecular…
Read ArticleIn an animal model, 0.89mM HRW also reduced disease severity, CNS infiltration, and demyelination when administered after the onset of disease. These preclinical findings add evidence supporting molecular…
Read ArticleIn mice, the mRNA expression of hypoxia-inducible factor 1 alpha and its immediate downstream target vascular endothelial growth factor (VEGF) showed significant elevation after laser, and this elevation…
Read ArticleIn rats, similarly, coenzyme Q9 levels in the rat plasma, myocardial tissue, and mitochondria were increased and malondialdehyde level in plasma was reduced after HRW administration. These preclinical…
Read ArticleIn rats, however, compared with the control group, exposure to 3% hydrogen significantly improved lung graft static compliance and oxygenation and remarkably decreased the wet-to-dry weight ratio, inflammatory…
Read ArticleIn the ischemia-reperfusion hydrogen-rich water group, PI3K, AKT and p-AKT mRNA and protein expression levels were increased while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased…
Read ArticleIn male Wistar rats, experiments on isolated aortic preparations from MCT rats showed that the addition of H₂ to the perfusion medium resulted in a 30% reduction in…
Read ArticleIn vitro experiments showed that hydrogen-rich medium mitigated the CT-1-induced cardiomyocyte hypertrophy with a similar effect as the JAK specific antagonists AG490. These preclinical findings add evidence supporting…
Read ArticleIn rats, vIP (OPLS-DA) analysis was performed with T test, and the metabolites of the control group and the hydrogen-rich water group were significantly different, and the glycerophospholipid…
Read ArticleIn rats, H₂ and XOR-I both suppressed MAP reduction and improved survival rates. H₂ did not affect XOR activity and the therapeutic effects of XOR-I and H₂ were…
Read ArticleIn rats, compared with MP, MP-H₂ treatment reduced lysophosphatidylinositol (LPI) levels and the LPI/phosphatidylinositol ratio while increasing phosphatidic acid (PA) species such as PA (18:0/18:1) and PA (18:0/20:4).…
Read ArticleIn rats, kEY FINDINGS: The myocardial infarct size, no-reflow area, cardiac function, microstructure and mitochondrial morphology of I/R model rats were significantly improved after hydrogen inhalation. These preclinical…
Read ArticleIn C57BL/6 mice, the study showed for the first time that HCH after myocardial I/R injury ameliorated myocardial injury in a mouse I/R model (67% H₂ ) and…
Read ArticleIn an animal model, the hydrogen gas level in liver tissue increased to 954.6 ppm immediately after reperfusion; however, it disappeared within 30 minutes. These preclinical findings add…
Read Article