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In male Wistar rats, compared with those in isoproterenol-MI group, hydrogen-rich saline decreased malondialdehyde and 8-hydroxy-desoxyguanosine concentrations, enhanced superoxide dismutase and Na(+)-K(+)-ATPase activity, lowered Ca(2+)-ATPase activity and decreased interleukin-6 and tumour necrosis factor-α levels in the serum and/or cardiac tissue of rats.…
Read ArticleIn rats, myocardial injury and inflammatory events were significantly attenuated by organ storage in the hydrogen-rich water bath. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn mice, kEY FINDINGS: H2W consumption significantly attenuated plaque formation and enhanced plaque stability in ApoE-/- mice, accompanied by altered gut microbiota structure and short-chain fatty acid profiles.…
Read ArticleIn mice, the survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased,…
Read ArticleIn rats, hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity. However, hydrogen…
Read ArticleIn mice, mHW intake improved cardiac hypertrophy, shortened the width of cardiomyocytes, dilated the capillaries and arterioles, activated myocardial eNOS-Ser-1177 phosphorylation, and restored left ventricular function in DIO…
Read ArticleIn C57BL/6 mice, although the increase in superoxide anion production did not significantly differ between the hydrogen and control groups, DNA damage was decreased as a result of…
Read ArticleIn rats, compared with the ischemic period, the ischemia-reperfusion phase showed significantly increased SOD activity and significantly decreased MDA content in the hydrogen-rich water group, while SOD activity…
Read ArticleIn an animal model, inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. These…
Read ArticleIn Wistar rats, 25 proteins that are involved in hydrogen-water reducing MIRI were selected by high-throughput GSR-CAA-67. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn male Wistar rats, hW intake may prevent lipid deposition in the rat aorta induced by periodontitis by decreasing serum ox-LDL levels and aortic oxidative stress. These preclinical…
Read ArticleIn male Sprague-Dawley rats, sTZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of…
Read ArticleIn an animal model, inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn rats, using this system, the concentration of H₂ in unit volume can be greatly improved under normal temperature and pressure conditions. These preclinical findings add evidence supporting…
Read ArticleIn male Wistar rats, the apoptosis rate was significantly decreased in the hydrogen-rich water group, as well. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
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