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In mice, the expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn male HR-1 hairless mice, however, no significant difference was observed between the H₂ -treated and control groups, most likely due to the long-term accumulation of lipid oxidation…
Read ArticleThese preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn Balb/c mice, as shown in Figure 2, HRW treatment decreased MDA levels in tumor tissues compared to control ( P < 0.05) and 5-FU treatment ( P…
Read ArticleIn mice, hydrogen pretreatment upregulated ROS and the expression of pyroptosis-related proteins, and increased the number of PI- and TUNEL-positive cells, as well as the release of LDH…
Read ArticleIn rats, iVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were…
Read ArticleIn rats, semi-quantitative scoring of the lung tissue in different groups showed that the lung tissue injury score of MCT group was significantly higher than that of SHAM…
Read ArticleIn rats, the exposure of H₂ together with monocrotaline (MCT), despite individual differences between animals, tended to decrease the intrapulmonary MC population and the severity of the fibrotic…
Read ArticleIn rats, H₂ gas-treated rats exposed to CIH showed a significant reduction in 8-hydroxy-2 deoxyguanosine content and increases in superoxide dismutase activity, indicating improved oxidative stress. These preclinical…
Read ArticleIn comparison to control rats given distilled water (DW), the researchers found that HW did not significantly influence systolic blood pressure (SBP) or diastolic blood pressure (DBP) in…
Read ArticleIn male Sprague-Dawley rats, hydrogen-rich water treatment improved hemodynamics and reversed right ventricular hypertrophy. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…
Read ArticleIn conclusion, consumption of HW is a promising strategy to alleviate renal injury as a supplement for anti-hypertensive therapy. These preclinical findings add evidence about the molecular-hydrogen effects,…
Read ArticleIn male Sprague-Dawley rats, molecular hydrogen ameliorates MCT-induced PAH in rats by suppressing macrophage accumulation, reducing oxidative stress and modulating the STAT3/NFAT axis. These preclinical findings add evidence…
Read ArticleIn rats, it has also been reported that, whereas either drinking hydrogen water or intermittent inhalation of 2% H₂ gas had favorable effects in a rat model of…
Read ArticleIn rats, H₂ significantly suppressed increases in blood pressure after 5/6 nephrectomy. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
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