Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study.
In 20 patients, after 2 weeks of hydrogen therapy, the number of exhausted and senescent cytotoxic T cells decreased to within the normal range, and there was an increase in killer Vδ1 cells.
Read MoreAcute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study.
Hydrogen-rich water did not significantly affect time to exhaustion, post-exercise blood lactate, maximal heart rate, or oxygen uptake.
Read MoreAcute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females
In 14 healthy participants with crossover design, ln SDNN was significantly increased after HRW administration when compared to placebo in 45 min (HRW: 4.41 ± 0.42 ms, placebo: 4.28 ± 0.31 ms, p =.049) of rest sitting. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence cardiac autonomic regulation in healthy women.
Read MoreEffects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.
In 18 patients with PD (age 30-80 years), this novel, proof-of-concept study demonstrated that PBM+H₂ therapy is safe and reduces disease severity. This small, pilot study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.
Read MoreEffect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
In 30 participants, however, the effect of hydrogen-rich water on symptoms was not significantly different from that of placebo, although supplementation with hydrogen-rich water was extremely effective in improving the bladder pain score in 11% of the patients.
Read MoreClinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy.
In participants with cervical cancer undergoing CCRT were prospectively enrolled and randomized into an experimental group (n = 28) or a cont, no significant difference in tumor response was observed between groups based on the Response Evaluation Criteria in Solid Tumors, suggesting that hydrogen therapy did not interfere with the antitumor efficacy of CCRT. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreHydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.
In 0 patients with potential metabolic syndrome, serum analysis showed that consumption of H₂-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. This small study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.
Read MoreThe Effect of Electrolyzed Hydrogen-Rich Alkaline Reduced Water on Patients with Chronic Constipation—A Clinical Trial
In 5 patients, electrolyzed hydrogen-rich alkaline reduced water (EHARW) helps treat gastrointestinal disorders owing to its various bioactive properties.
Read MoreApplication of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans.
In 18 healthy, trained participants, hCP increased absolute values of deoxy[Hb + Mb] at the RF but not VL. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreComparative Proteomic Analysis during the Involvement of Nitric Oxide in Hydrogen Gas-Improved Postharvest Freshness in Cut Lilies.
In participants, 1% hydrogen-rich water (HRW) and 150 μM sodium nitroprusside (SNP) significantly extended the vase life and quality, while NO inhibitors suppressed the positive effects of HRW. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise.
A significantly lower blood lactate was found with HRW (4.0±1.6 and 8.9±2.2 mmol.l-1) compared to Placebo (5.1±1.9 and 10.6±3.0 mmol.l-1) at 3.0, and 4.0 W.kg-1, respectively.
Read MoreMolecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players.
In participants, sprint time at 30 m also significantly improved by 1.9% in the HRW group in the last sprint. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.
Read MoreInhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.
In 10 participants, H₂ significantly augmented breath acetone and enhanced oxygen uptake during exercise (P < 0.01). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals.
In 118 participants with mild-to-moderate dry eye symptoms, a significant decline in fTBUT was observed in the placebo group (p = 0.04), but not the H₂-producing group (p = 0.26). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
Read MoreElectrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.
In participants with chronic HD were enrolled and received ERW administration for 6 month, hD resulted in decreased plasma VC, total antioxidant status, and erythrocyte metHb/ferricyanide reductase activity and increased erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and plasma metHb. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
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