Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.

In 60 patients, after treatment, the oxidative stress remained unchanged in routine treatment group, but markedly improved in hydrogen treatment group. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation in healthy adults.

Read More

Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.

In 30 participants with NAFLD, HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.

Read More

Renal replacement strategies: dual benefits of hydrogen gas inhalation and hydrogen-enriched dialysate.

In 300 participants with correspondingly higher plasma ORP levels compared with control subjects, by investigating this novel approach, the researchers aim to contribute to the growing body of evidence supporting the integration of H₂ into RRT for improved patient outcomes. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence blood-pressure regulation.

Read More

Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.

In 8 patients, however, the mean proportion of reversibly oxidized albumin in outlet serum was significantly lower than that in inlet serum following the H₂-HD session, whereas no significant changes were found in the standard solution session, suggesting that "intra-dialyzer" OS is reduced by H₂ -HD. This human hemodialysis study evaluated an H₂-enriched solution. Redox or peroxide terminology describes the biological context and does not change the identity of the molecular-hydrogen intervention.

Read More

Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.

In Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the respective HD treatments during the study, during the 3.28-year mean observation period, there were no differences in dialysis parameters between the two groups. However, post-dialysis hypertension was ameliorated with significant reductions in antihypertensive agents in the E-HD patients. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence blood-pressure regulation.

Read More

Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.

In 21 patients, anti-inflammatory cytokine IL-10 levels significantly increased after hydrogen-rich water therapy, while inflammation-related cytokines VEGF and TGF-β levels significantly decreased. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.

Read More

Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.

In 30 participants, however, the effect of hydrogen-rich water on symptoms was not significantly different from that of placebo, although supplementation with hydrogen-rich water was extremely effective in improving the bladder pain score in 11% of the patients.

Read More

The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial.

This human study examined the effect of drinking HRW on the severity of premenstrual symptoms and the quality of life of women who suffer from PMS. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans.

In 24 healthy participants, the thermograms indicated that, under the same conditions (41 °C, 10-min bathing), hydrogen-rich water bath (hydrogen concentrations: 185-548 μg/L; oxidation-reduction potentials: -167 to -91 mV, versus 0.8 μg/L and +479 mV for normal bath, respectively) brought about the heat-retention being more marked than those of normal water bath for several body-parts in the order as follows. Abdomen > upper legs > arms > hands > feet, for 30- and 60-min post-bathing, being in contrast to scarce heat-retention for head, armpits and lower legs. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss.

In participants with ISSNHL to receive either H₂ (H₂ group) or air as a placebo (control group) through inhalation combined with the administ, the hearing threshold 3 months after treatment was not significantly different between the groups; 39.0 decibels (dB) (95% confidence interval [CI]: 28.7-49.3) and 49.5 dB (95% CI: 40.3-58.7) in the H₂ and control groups, respectively. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial.

In The participants drank 500 mL of purified tap water or AEW every day for 2 weeks, the authors' hypothesis on the effectiveness of alkaline electrolyzed water (AEW) proposes that ingestion of AEW, considered possessing antioxidative properties, increases the number of Bifidobacteria and improves stool hardness and gastrointestinal symptoms. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial.

These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa.

These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More

The impact of perioperative hydrogen gas inhalation on postoperative recovery in day surgery patients: a research study.

In exploratory analyses, the hydrogen group also showed descriptive trends toward lower pain scores, greater physical independence, and improved sleep quality. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.

Read More

Association of Self-Selected Hydrogen-Rich Water Consumption with 6-Month Changes in Chair-Stand Performance and Gait Speed among Community-Dwelling Older Adults Attending Community Salons.

In 128 participants, self-selected hydrogen-rich water consumption was associated with better chair-stand performance and gait speed in this pragmatic community setting, but residual confounding remains possible. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

Read More