Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms.

(2) Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms.

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Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training.

In 12 participants,, an acute intermittent HRW hydration improved muscle function, reduced the lactate response, and alleviated delayed onset of muscle soreness. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery.

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The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise.

In 6 participants, this pilot study suggests that the whole-body bathing in supersaturated HRW is a safe procedure that attenuates muscular damage and can ease sore muscles after high-intensity eccentric exercise. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

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Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects.

In 1 trained participants, after HRW intake, only trained cyclists improved their performance in the anaerobic test with an increase in peak power (from 766.2 ± 125.6 to 826.5 ± 143.4 W; d =.51) and mean power (from 350.0 ± 53.5 to 380.2 ± 71.3 W; d =.51), and a decrease in the fatigue index (from 77.6 ± 5.8 to 75.1 ± 5.9%; d =.45). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.

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Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study 1.

In these healthy non-trained participants (n = 99), psychometric fatigue judged by visual analogue scales was significantly decreased in the H₂ group after mild exercise. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.

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Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study.

In 8 healthy participants, HRW decreased exercising HR during minutes 1-9 of the graded exercise test (121 ± 26 bpm) compared to placebo (126 ± 26 bpm) and baseline (124 ± 27 bpm) (p < 0.001) without substantially influencing VO2. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery in healthy adults.

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Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.

In 8 physically active participants, after exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery.

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Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise.

In 24 young participants, it was observed that compared to control, after inhaling H₂ gas, participants had significantly lower RPE at each workload phase (p < 0.032) and lower HR at 50% Wmax, 75% Wmax, and 100% Wmax during cycling exercise (p < 0.037); the PFC activation was also significantly increased at 75 and 100% Wmax (p < 0.011). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.

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Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study.

In In this double-blind, randomized, crossover study, participants ingested H₂-producing milk that induced intestinal bacterial H₂ production or a placebo on the trial day, 4 h before performing an inten, lipid oxidation AUC was 1.3-fold higher significantly with H₂-producing milk than with placebo consumption. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery.

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Short-term H2 inhalation improves running performance and torso strength in healthy adults.

In 10 participants with a wash-out period of 7 days to prevent the residual effects of interventions across study periods, breathing 4% hydrogen for 20 min per day resulted in increased peak running velocity (by up to 4.2%) as compared to air inhalation (P = 0.05). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.

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The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial.

In 27 apparently healthy, middle-aged participants (18 women), HRW significantly outperformed the control water in reducing biomarkers of acute muscular damage caused by resistance exercise (p ≤ 0.05); the sleep quality difference favored HRW but was not statistically significant (p = 0.119). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes.

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Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat.

In In a double-blind crossover with counterbalanced trials, all participants underwent a shuttle run test after 30 min under the following conditions: (1) hydrogen-rich cold water ingestion (HRCW),, findings from this study suggest that ingesting hydrogen-rich cold water effectively mitigates the effects of heat stress, thereby improving endurance performance, enhancing mood, and reducing ratings of perceived exertion. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.

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Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.

In 22 participants with 22 female elite athletes participating in handball and skeleton sports, HRW intake led to a reduction in total creatine kinase, vitamin C, and beta-carotene contents (p < 0.05), whereas the vitamin E and interleukin-10 levels increased compared with baseline levels (p < 0.05). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.

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Inhalation of Hydrogen-rich Gas before Acute Exercise Alleviates Exercise Fatigue: A Randomized Crossover Study.

In 24 healthy participants, compared to a placebo, HRG inhalation induced significant improvement in VAS, RPE, the cycling frequency during the last 30 seconds in the fatigue modeling process, the ability to inhibit hydroxyl radicals, and serum lactate after exercise (p<0.028), but not in countermovement-jump height and glutathione peroxidase activity. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes in healthy adults.

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The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial.

In 55 participants, this study demonstrates that HRW might be an effective strategy for alleviating fatigue and improving cardiorespiratory endurance, musculoskeletal function, and sleep quality. This pilot study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.

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