The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study.
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
Read MoreThe Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial.
In 120 patients with CR were randomly divided into two groups, compared to saline irrigation, HRS nasal irrigation was found to improve CR clinical symptoms, especially in patients with AR. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
Read MoreThe effect of hydrogen gas on the oxidative stress response in adipose tissue.
In 12 patients with a mid-thoracic incision, the immunostaining results showed that HO-1 and Nrf2 expression levels were significantly decreased in the hydrogenated group, whereas SOD expression levels increased, but did not attain statistical significance. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreThe Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial.
The results demonstrated that hydrogen-rich water significantly mitigated cravings (p = 0.05), improved subjective sleep quality (p = 0.05), reduced total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and increased plasma glucagon-like peptide-1 levels (p = 0.05) compared to the control. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes.
Read MoreMolecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.
In 10 middle-aged participants, it appears that orally administered H₂ as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence glucose regulation and metabolic health.
Read MoreA randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas.
In Both groups received standard treatment plus 4 daily 1-h interventions for 14 consecutive days, although it is generally safe and feasible, its potential effects on myocardial, liver and gastrointestinal functions of children need to be closely monitored. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers.
In 16 apparently healthy, young participants, both HRW and caffeine significantly increased the choline-to-creatine ratio in several brain regions (frontal white and gray matter), while HRW and the combination intervention also affected brain metabolism in the paracentral brain. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes in healthy men.
Read MoreHydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records.
The results showed significant decreases in the neutrophil percentage and the concentration and abnormal proportion of C-reactive protein in COVID-19 patients received additional hydrogen-oxygen therapy. This novel therapeutic may alleviate clinical symptoms of COVID-19 patients by suppressing inflammation responses. This small study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.
Read MoreHydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.
In 9 patients with hypercholesterolemia and their underlying mechanisms in a double-blinded, H₂ treatment increased the effective rate in down-regulating plasma levels of total cholesterol (47.06% vs 17.65%) and LDL cholesterol (47.06% vs 23.53%). These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome.
Read MoreHydrogen-rich water affected blood alkalinity in physically active men.
In 52 physically active, healthy participants, intake of HRW significantly increased fasting arterial blood pH by 0.04 (95% confidence interval; 0.01 - 0.08; p < 0.001), and postexercise pH by 0.07 (95% confidence interval; 0.01 - 0.10; p = 0.03) after 14 days of intervention. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreMolecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study.
In Twenty, physically active female participants aged 22, compared with placebo (ambient air), molecular hydrogen inhalation significantly decreased respiratory exchange ratio and ventilation across all intervals. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.
In 26 participants with a two-way crossover design, these results suggest that HRW may reinforce QOL through effects that increase central nervous system functions involving mood, anxiety, and autonomic nerve function. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreHydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MoreThe Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.
In 30 patients with NAFLD and 15 healthy volunteers were included in this clinical trial, after 8 weeks of adjuvant therapy with HRW, the concentration of CoQ10 in platelets increased, plasma TBARS decreased, and the efficiency of OXPHOS improved, while in the P group, the changes were non-significant. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
Read MorePossible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.
In 262 patients, the data indicates E-HD could have substantial clinical benefits beyond conventional HD therapy, and support the rationale to conduct clinical trials of H₂ application to HD treatment. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.
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