Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function.
This animal study examined Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function. The abstract describes Rat model; reported duration 3 hours. The abstract reports: In conclusion, HMP and H gas treatment are partly effective in DCD rat livers but insufficient. Hypothermic machine perfusion can improve focal microcirculation and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine.
This animal study examined Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. The abstract describes Porcine model; sample size 14; reported duration 20 min. The abstract reports: H2 gas attenuates markedly ischemia and portal hyperperfusion injury in pigs with massive hepatotectomy, possibly by the reduction of inflammation and oxidative stress, maybe…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.
This randomized controlled trial examined Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 28 days. The abstract reports: Although preliminary, the results of this trial perhaps nominate HRW as an adjuvant treatment for mild-to-moderate NAFLD. These observations provide a rationale for further…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats.
This animal study examined Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HS attenuates the massive hepatectomy induced liver injury not only by attenuating oxidative damage, but also by reducing the production of inflammatory cytokines, such…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.
This animal study examined Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS is able to protect against AKI after liver transplantation partly by reducing apoptosis, which is possibly involved in the modulation of p53-mediated autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDelivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications
This narrative review examined Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications. The abstract describes Published literature review. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.
This in vitro or cellular study examined Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury. The abstract describes Cell culture / in vitro model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.
This uncontrolled human study examined The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease. The abstract describes Human participants; sample size 30; hydrogen delivered as hydrogen water; reported duration 8 weeks. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease.
This animal study examined Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation; reported duration 10 weeks. The abstract reports: Liver transcriptomic data suggested that H treatment significantly downregulated inflammatory response genes, and the lipopolysaccharide (LPS)/Toll-like receptor (TLR) 4/nuclear transcription factor kappa B (NF-κB)…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCombination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers
This animal study examined Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers. The abstract describes Rat model. The abstract reports: Multiple comparison tests among the UW, Dsol, UW-H, and Dsol-H groups revealed that both treatments, during CS and after reperfusion, conferred a similar extent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation.
This animal study examined Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation. The abstract describes Mouse model; reported duration 4 days. The abstract reports: Therefore, the results of the present study demonstrated that treatment with exogenous H by intraperitoneal injection may alleviate acute alcohol-induced liver injury by inhibiting…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreConcomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and N‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats
This animal study examined Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and N‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 1 month. The abstract reports: Both hydrogen-rich saline and N-acetylcysteine alleviate portal hypertension, the severity of portosystemic collaterals, mesenteric angiogenesis, hepatic endothelial dysfunction and intrahepatic resistance in cirrhotic rats.…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen treatment: a novel option in liver diseases.
This narrative review examined Hydrogen treatment: a novel option in liver diseases. The abstract describes Published literature review. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
This animal study examined Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. The abstract describes Mouse model; reported duration 90 min. The abstract reports: We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and laparoscopic hepatectomy in swine.
This animal study examined Hydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and laparoscopic hepatectomy in swine. The abstract describes Porcine model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS treatment may exert a protective effect against I/R and hepatectomy-induced hepatic damage by reducing oxidative stress, suppressing the inflammatory response and promoting liver…. This is an automated editorial draft based on the abstract and requires source review before publication.
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