Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
The researchers found that H₂-O₂ mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac apoptosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes…
Read ArticleIn a laboratory model, hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. The authors concluded that preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory…
Read ArticleIn rats, these data suggested that pharmacological postconditioning with lactic acid and hydrogen rich saline nearly replicates the benefits of mechanical postconditioning. These preclinical findings add evidence supporting…
Read ArticleThe researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis…
Read ArticleIn mice, hydrogen gas is recently proven to have anti-oxidative and anti-inflammation effects on ischemia-reperfusion injury. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn a laboratory model, molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating endothelial cells; the most pronounced effect was observed after repeated…
Read ArticleIn mice, intermittent hypoxia significantly increased plasma levels of low- and very low-density cholesterol and the amount of 4-hydroxy-2-nonenal-modified protein adducts in the LV myocardium. These preclinical findings…
Read ArticleIn male Wistar rats, during mild SI, H₂ reduced plasma surges of proinflammatory cytokines (TNF-α and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented…
Read ArticlePropose that the cardiovascular benefits of alpha-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H(2) in the gastrointestinal tract. This…
Read ArticleIn In a randomized, double-blind study design, all players ingested 500 mL of HRW or placebo (PLA) supplement 30 min before the start of the tests, 500 mL…
Read ArticleIn rats, neuronal degeneration and microglial activation in a vulnerable brain region was suppressed by both TTM alone and H₂ inhalation alone, with the combined therapy of TTM…
Read ArticleIn Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage, hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic…
Read ArticleIn Neuronal degeneration within hippocampal Cornu Ammonis 1 (CA1) regions was examined by Fluoro-Jade staining ex vivo, both hydrogen gas treatment regimens significantly improved spatial learning function and…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Hydrogen (H₂) is colorless, odorless, and the lightest of gas molecules. The reviewed evidence adds support for molecular hydrogen's therapeutic…
Read ArticleH2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen ischemia-reperfusion study 2020…
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