Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreAlleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes.
After a single postexercise intervention, the H₂ group showed improved antioxidant capacity and reduced WBC and CRP levels. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated Inflammasome Inactivation in Neuropathic Pain Rats.
In an animal model, focused on the mechanism and role of autophagy and inflammasome, by which hydrogen alleviated the hyperpathia induced by neuropathic pain. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreSupersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report
In 57 participants, this case is yet another indication that high-concentration hydrogen-rich hydrotherapy may be a helpful first line treatment in terms of reduction of pain and improvement in function following injury, in addition to the evidence suggesting benefit in reducing chronic indications caused by acute or chronic stress. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreTwo weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study.
In 20 patients, after 2 weeks of hydrogen therapy, the number of exhausted and senescent cytotoxic T cells decreased to within the normal range, and there was an increase in killer Vδ1 cells.
Read MoreHydrogen Gas from Inflammation Treatment to Cancer Therapy.
Nanocarrier-mediated H₂ delivery, as well as in situ production of H₂ by nanogenerators, can significantly improve targeted accumulation of the gas and accelerate the therapeutic effects. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreEstimation of Molecular Hydrogen Consumption in the Human Whole Body After the Ingestion of Hydrogen-Rich Water
Seven healthy adults were studied after they consumed hydrogen-rich water. Breath hydrogen increased rapidly and was near baseline within about an hour. The researchers reported that much of the ingested hydrogen was exhaled and that a substantial remainder was consumed or retained in the body. This small physiology study was not designed to measure a health outcome or treatment effect.
Read MoreBiological Responses to Hydrogen Molecule and its Preventive Effects on Inflammatory Diseases.
However, the researchers showed previously that inhalation of H₂ markedly suppresses brain injury induced by focal ischemia-reperfusion by buffering oxidative stress. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreOxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen and molecular oxygen that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through
This narrative review examined the biological rationale and early clinical evidence for oxy-hydrogen inhalation in respiratory conditions. The authors highlighted early evidence of cytoprotective, antioxidant, and anti-inflammatory effects. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
In rats, the data showed that the spatial recognition memory and fear memory of the rats treated with sevoflurane decreased compared with the control, and the cognitive function of the rats treated with sevoflurane and hydrogen gas significantly increased in comparison with treatment with sevoflurane alone. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreThe role of IL-6 on apical periodontitis: a systematic review.
Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis - Bai - Annals of Translational Medicine is classified as Meta-analysis using Review or synthesis. The primary model is Published literature review. Detailed outcomes require source review because an abstract was not accessible.
Read MoreProtective effects of hydrogen rich saline solution on ventral penile mathieu type flap with penile tourniquet application in rats.
In rats, molecular hydrogen can easily attach to biomembranes and enter cytosol, mitochondria and other organelles of the cell and convert the formed OH- to H₂O to prevent cell and tissue damage. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreClinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy.
In participants with cervical cancer undergoing CCRT were prospectively enrolled and randomized into an experimental group (n = 28) or a cont, no significant difference in tumor response was observed between groups based on the Response Evaluation Criteria in Solid Tumors, suggesting that hydrogen therapy did not interfere with the antitumor efficacy of CCRT. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read MoreColonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats.
In rats, reduced cytokine expression by FOS feeding might be dependent on increased colonic H₂. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreInvolvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath.
These results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H₂ bath is effective for the inflammatory process that was centered on neutrophils after downhill running. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
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