Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In mice, intrathecal delivery of recombinant CXCL1 induces acute allodynia and spinal iron overload, which is reversed by hydrogen-rich water. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn an animal model, an in vitro study performed on RAW264.7 murine cells showed that H₂ treatment prevents RANKL-associated osteoclastogenesis, inhibiting the inactivation of NF-kB, mitogen-activated protein kinase…
Read ArticleIn mice, H₂ treatment reduced inflammatory, oxidative, and fibrotic lung changes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured…
Read ArticleIn mice, the immunofluorescence of cleaved caspase-3 also indicated that H₂ suppressed the expression of cleaved caspase-3 in TBHP-induced chondrocytes ( Figure 5H ). These preclinical findings add…
Read ArticleIn rats, mDA and 8-OHdG were significantly decreased in hydrogen-rich medium, while SOD and GSH were increased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn 1 patients, iL-6 levels in the H₂ group significantly decreased in 4 weeks by 37.3 ± 62.0% compared to baseline, whereas it increased by 33.6 ± 34.4%…
Read ArticleIn male Sprague-Dawley rats, the wet/dry ratio increased significantly in the IR group (P < 0.01 compared with that in the sham group) and decreased significantly in IR…
Read ArticleIn 20 patients with rheumatoid arthritis (RA), during the first 4 weeks, 8-OHdG decreased in 17 of these patients after drinking the high H₂ water. These findings add…
Read ArticleIn 3 patients, iL-17, whose concentration was high in Case 1, was reduced following H₂ treatment, and TNFα also decreased in Case 1. These findings add human evidence…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. By drinking 500 ml of the high H₂ water daily for four weeks, oxidative stress was effectively reduced and the…
Read ArticleIn a laboratory model, H₂ decreased the levels of the nitrated proteins, and suppressed chondrocyte death. The authors concluded that moreover, novel pharmacological strategies aimed at selective removal…
Read ArticleIn mice, the amount of trabecular bone and bone mineral density of OVX mice that inhaled H₂ were more than 40% higher, whereas the levels of serum proinflammatory…
Read ArticleRecently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. This source-grounded publication contributes evidence relevant to…
Read ArticleIn a laboratory model, treatment with hydrogen reduced LPS/IFNγ-induced NO release, which was associated with a diminished induction of inducible isoform of nitric oxide synthase (iNOS). The authors…
Read ArticleIn rats, drinking hydrogen-rich water suppressed body weight gain, lowered gingival level of 8-hydroxydeoxyguanosine, and reduced alveolar bone resorption in rats on a high-fat diet. These preclinical findings…
Read Article