Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In mice, the pivotal proteins involved in endoplasmic reticulum (ER) stress, including p-eIF2α, ATF4, XBP1s and CHOP, were dramatically reduced after HRW treatment in contrast to the control group (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, the oxidative stress levels of MDA and MPO in the gastric tissues increased significantly in the aspirin-treated group compared with the HRW group (2.43 ± 0.145…
Read ArticleIn vitro analysis of cytokine levels after LPS treatment of cultured macrophages showed an increase of interleukin-10 by hydrogen regardless of the presence of nitric oxide. The authors…
Read ArticleIn an animal model, body mass was 36.4 (35.1–37.9) and 36.9 (34.4–38.4) kg in the control and hydrogen groups, respectively ( p = 0.89). These preclinical findings add…
Read ArticleThe findings suggest that treatment with molecular hydrogen may affect microbiota profiling and suppress intestinal injury in HFD-loaded SAMP8. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleThese findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read ArticleIn the intestinal tissue, compared with the LPS group, the HRW + LPS group had decreased the levels of IL-1β and TNF-α ( Figure 2 B, p <…
Read ArticleIn mice, although sulfasalazine significantly reduced MDA levels compared to the colitis model (P < 0.001), H₂ with and without sulfasalazine was significantly more effective compared to sulfasalazine…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read ArticleIn male Wistar rats, the serum levels of TNF-α, IL-1β, and IL-6 were significantly increased 12 h after the onset of AP ( Fig 3A ), and the…
Read ArticleIn rats, hydrogen-rich saline also increased B-cell lymphoma 2 (Bcl-2) expression and the activity of the antioxidant enzyme superoxide dismutase (SOD). These preclinical findings add evidence supporting molecular…
Read ArticleIn rats, HRW treatment effectively alleviated the degenerative changes in the retinal outer nuclear layer, improved retinal function, and reduced retinal inflammation in treated rats. These preclinical findings…
Read ArticleIn a laboratory model, simultaneously, HPC treatment markedly increased the phosphorylations of Akt. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential…
Read ArticleIn mice, H₂ mice showed significantly higher retinal thickness as compared to controls on optical coherence tomography. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleThe researchers found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-κB but increased the expression of the DNA repair-related protein HMGB1, suggesting…
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