Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In C57BL/6 mice, levels of inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor α) and oxidative stress markers (ie, malondialdehyde) were significantly lower, whereas antioxidant enzyme (total superoxide dismutase) activity was higher in the nebulized hydrogen-rich water treatment group compared with the…
Read ArticleIn participants, clinical findings demonstrated improved arterial blood gases, acid-base balance, and exercise tolerance in elderly COPD patients. These findings add human evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Taken together, accumulating experimental evidence indicates that H₂ can significantly alleviate transplantation-related lung injury, mainly via inhibition of inflammatory cytokine…
Read ArticleA single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD. This source-grounded publication contributes evidence relevant to molecular hydrogen…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. However, a clinical trial showed that inhaling a mixture of 1.2–1.4% molecular hydrogen–air increased urinary 8-hydroxy-2′-deoxyguanosine, a marker of oxidative…
Read ArticleIn mice, hydrogen-rich water treatment at doses of 2.5, 5, or 10 ml/kg significantly attenuated LPS-induced pulmonary fibrosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, at P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. These preclinical findings…
Read ArticleIn an animal model, administration of H₂-rich water attenuated the CS-induced lung damage in the SMP30-KO mice and reduced the mean linear intercept and destructive index of the…
Read ArticleIn 10 patients with chronic lung diseases due to COPD (n = 7), however, vitamin E, vitamin C, and nitrite levels showed a significant increase after 4 week…
Read ArticleIn mice, serum testosterone and FSH levels also increased, while serum ROS level decreased (all P <0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn mice, these were 1.4-fold, 1.5-fold, 1.6-fold and 1.7-fold higher than those of the non-H₂ groups, which were 77.7%, 45.9%, 27.1% and 18.8% of normal nonirradiated control level…
Read ArticleIn rats, although placental weight and the number of fetuses had no significant difference among groups, the placental efficiency significantly increased after the oral administration of HRW to…
Read ArticleIn female BALB/c mice, the GC AI was significantly higher in the model group (21.30 ± 1.74%) than those in the control (7.06 ± 0.27%), hydrogen (5.17 ±…
Read ArticleIn HRW treatment of POF rats, the serum AMH and E2 levels significantly increased, and FSH level significantly reduced, indicating the protective role of HRW. These preclinical findings…
Read ArticleIn rats, the study has systematically elucidated the molecular mechanism of HRW against ionizing radiation, which can be mediated by modulating targets, pathways and metabolite levels. These preclinical…
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