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In MHY1485, an mTOR activator, abolished the protective effects of hydrogen in vitro, hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2…
Read ArticleIn The cells were resuspended in DMEM supplemented with 10% (v/v) FBS, 1% (v/v) penicillin and streptomycin to adjust the cell density to 1.5×10 6 /ml, H₂ alleviated…
Read ArticleIn Animal models of SAE were generated by cecal ligation and puncture, and the SAE model was established by in vitro LPS stimulation, finally, hydrogen treatment improved the…
Read ArticleIn a laboratory model, on day 3 of ischemia/reperfusion, the number of neurons undergoing apoptosis in the cortex was significantly lower in the H₂-rich saline group than in…
Read ArticleIn a laboratory model, hydrogen-rich saline treatment could inhibit apoptosis and inflammation while no significant reduction was observed in nitrogen-rich saline treated animals. The authors concluded that the…
Read ArticleIn As a mechanism study, only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated ·OH-generating system, indeed, the phagocytic indices increased to 3.5 and 6.7 folds at…
Read ArticleIn a laboratory model, western blot analysis showed that hydrogen significantly upregulated the levels of phosphorylated AMPK (p-AMPK) and lowered the LPS-induced increased expression of dynamin-related protein 1…
Read ArticleIn A549 and NCI-H292 cells utilized in this study were obtained from the Korean Cell Line Bank (Cancer Research Institute of Seoul National University, Seoul, Korea), H₂O₂ stimulation…
Read ArticleIn a laboratory model, hydrogen ameliorated cell injury and enhanced mitophagy in macrophages stimulated by LPS. The authors concluded that these results suggest that PINK1-mediated mitophagy plays a…
Read ArticleIn a laboratory model, the expression of TNF-α was increased by 100 μmol/L vitamin C and 50 μmol/L vitamins E, separately or combined (P < 0.05), but not…
Read ArticleIn GC-1 spermatogonial cells and TM-3 Leydig cells, two well-established male reproductive cell lines, were exposed to NEMP, specifically, molecular hydrogen reduced the production of ROS and restored…
Read ArticleIn a laboratory model, it was confirmed by immunofluorescence that hydrogen treatment could restore the expression of autophagy marker protein LC3 (microtubule-associated protein 1 light chain 3) in…
Read ArticleIn vivo administration of H₂ to pregnant mice regulated inflammatory responses and reduced PTB caused by T cell activation, which further supports the notion that H₂ may contribute…
Read ArticleIn In vitro experiments using the IEC-6 cell line showed that hydrogen-rich medium significantly inhibited ROS formation, maintained cell viability, and inhibited cell apoptosis, hydrogen treatment decreased cellular…
Read ArticleIn HW specifically decreased hydroxyl radical (∙OH) levels in the c-kit+ cells of 4 Gy irradiated mice, the mean fluorescence intensity (MFI) of γ-H2AX and percentage of 8-oxoguanine…
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