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In rats, serum IL-6 levels 2 hours after ROSC were not significantly increased in post-CA rats of the H₂ group (848.9±257.0 pg/mL) or H₂ +TH group (933.3±339.0 pg/mL) compared with sham-operated rats, but in the H₂ +TH group, serum IL-6 levels were…
Read ArticleIn mice, compared with female mice, H₂ administration post-ICH exhibited fewer neuroprotective effects, including decreased sucrose consumption and time spent sniffing a novel mouse, increased immobility time, downregulated…
Read ArticleIn mice, the infarct volume of mice in the HRS‑H group decreased significantly compared to that of the distal middle cerebral artery occlusion (dMCAO) group. These preclinical findings…
Read ArticleIn male Wistar rats, however, inhalation of H₂ gas after ROSC significantly decreased the number of abnormal mitochondria and increased the relative mitochondrial mass in rat LVs, and…
Read ArticleIn the H₂ treatment group (group H), these proteins were significantly decreased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleIn an animal model, nissl staining demonstrated a significant decrease in the number of nissl-stained dark neurons (N-DNs) in HI group compared to TBI group at 2 h…
Read ArticleIn an animal model, the inhalation of 42% H₂ for one hour per day for 48 h significantly reduced brain edema, decreased the extravasation of sodium fluorescein, and…
Read ArticleIn rats, effect of hydrogen on S100- β and NSE levels The levels of S100-β and NSE have similar trends, these increased in the I/R group compared with…
Read ArticleIn rats, hydrogen-rich water administration significantly increased 7-d survival rates, reduced neurologic deficits, and lowered intracellular oxidative stress levels. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn Sprague-Dawley rats, bcl-2 was significantly increased while Bax and cleaved caspase-3 was decreased by HS treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement…
Read ArticleIn mice, hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content,…
Read ArticleIn rats, these results demonstrated that H₂ significantly reduced the number of apoptotic cells, and the protein expression of p38 MAPK and caspase‑3, compared with the IR group.…
Read ArticleIn Sprague-Dawley rats, hydrogen administration reduced the expression of 8-OHdG in the brain, but did not attenuate brain water content or improve functional outcome, regardless of administration route.…
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