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In male Sprague-Dawley rats, hydrogen treatment significantly reduced the level of oxidative stress, neuroinflammation, neuronal damage, and apoptosis-related genes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleThe results demonstrated that TBI-challenged rats exhibited significant brain injuries that were characterized by decreased survival rate and increased BBB permeability, brain edema, and neurological dysfunction, while HRW…
Read ArticleIn mice, the hydrogen inhalation reduced these effects acutely (24 h); however it exhibited only a tendency to improvement in the delayed study (72 h). These preclinical findings…
Read ArticleIn rats, the beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. These preclinical findings…
Read ArticleIn rats, HRW treatment improved neurological function and tended to improve overall survival but without significant difference. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn rats, rats undergone global cerebral I/R and treated with HRS have milder injury than I/R animals without HRS treatment. miR-210 expression in the hippocampus of the I/R…
Read ArticleIn this CA rat model, inhaling 2% hydrogen combined with a high concentration of oxygen improved 96-h survival, either under normothermia or under hypothermia. These preclinical findings add…
Read ArticleIn an animal model, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (BDNF)-mediated synaptic plasticity, improved cognitive performance in the Morris…
Read ArticleIn male Wistar rats, the neuronal density 3·3±2·1 cells/mm in CA1 region of the ischemic rats increased to 21·7±2·6 cells/mm after they were treated with hydrogen gas. These…
Read ArticleThe researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis…
Read ArticleIn rabbits, no significant difference was observed between the two CA groups treated with different doses of H₂. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, the Kaplan-Meier analysis showed that H₂ significantly improved the 4 h-survival endpoint (log-rank P = 0.025 vs. placebo). These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleThe researchers found that HS treatment increased the endogenous antioxidant enzymatic activities and decreased the oxidative product levels in brain tissues of TBI-challenged rats. These preclinical findings add…
Read ArticleIn rats, neuronal degeneration and microglial activation in a vulnerable brain region was suppressed by both TTM alone and H₂ inhalation alone, with the combined therapy of TTM…
Read ArticleThe researchers observed that H₂ treatment significantly (P = 0.0232) improved the 7-day survival rate of mice, from 8.3% (BCCAO group, n = 12) to 50% (BCCAO +…
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