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In rats, hypoxia–ischemia induced neuronal damage and increased the expression of the apoptotic factors, P-JNK, and p53, which were attenuated by hydrogen inhalation (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleThe results of the current study demonstrated that HS significantly reduced behavioral, biochemical and molecular effects caused by DPN. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn rats, eLISA analysis showed decreased TNF-α and IL-1β and increased IL-10 expression levels in the hydrogen-rich saline-treated group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn mice, H₂ reduced the LPS-induced expression of pro-inflammatory cytokines, oxidative damage and microglial activation in the fetal brains. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleThe results showed the expression of PPARα was decreased in SAE mice and that activation of PPARα in septic mice improved the survival rate and alleviated cognitive dysfunction.…
Read ArticleIn conclusion, combined H₂ gas ventilation and TH increased CBV and decreased ScO2, which may reflect elevated cerebral blood flow to meet greater oxygen demand for the surviving…
Read ArticleIn an animal model, hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial…
Read ArticleIn an animal model, this study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory…
Read ArticleIn male Sprague-Dawley rats, however, HOS and HOHS significantly decreased COHb contents, furthermore, the HOHS group had lower COHb contents than the HOS group. These preclinical findings add…
Read ArticleIn mice, HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. These results are preclinical and suggest molecular hydrogen's…
Read ArticleIn rats, pretreatment with H₂ inhalation significantly attenuated seizure intensity; prevented neuronal loss; decreased microglial and astrocytic activation; decreased ROS, TNF-α, IL-1β, IL-6, CCL2 and CCL3 levels; and…
Read ArticleIn rats, the data from the elevated plus maze and the open field test showed that NEMP exposure elicited anxiety-like behavior in rats, which could be alleviated by…
Read ArticleIn mice, hyperbaric hydrogen therapy may be effective for posttraumatic secondary brain injury. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological…
Read ArticleIn mice, 5 In the present study, the researchers quantitatively assessed the changes in protein phosphorylation in the H₂ ‐treated CLP model mice and identified functions and signalling…
Read ArticleIn mice, the present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity)…
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