Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In an animal model, hydrogen could significantly reduce HALI by reducing lung edema and apoptosis, inhibiting the elevating of ERS and increased SIRT1 expression. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in…
Read ArticleIn male Sprague-Dawley rats, hydrogen saline significantly protected vasoactivity of the pulmonary artery, reduced pulmonary oedema, decreased lung malondialdehyde (MDA), 8-OHdG concentration, alleviated lung epithelial cellular apoptosis and…
Read ArticleIn rats, however, after treatment with HSS, all of these changes were alleviated (P < 0.05), and these changes were mitigated when treated with HSS by ip then…
Read ArticleIn rats, hyperoxia exposure increased glutathione content in lung homogenate (36%) more than hyperoxia+H₂ (21%), consistent with increases measured in Tc-HMPAO lung uptake. These preclinical findings add evidence…
Read ArticleIn rats, exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. Hydrogen inhalation did not affect hemodynamic status…
Read ArticleIn male Sprague-Dawley rats, treatment with saturated hydrogen saline prolonged the median survival time of rats and reduced lung dysfunction induced by LPS. These preclinical findings add evidence…
Read ArticleIn mice, hydrogen-rich water treatment at doses of 2.5, 5, or 10 ml/kg significantly attenuated LPS-induced pulmonary fibrosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleThe results indicated that PaO2, PaCO2, and T-SOD increased in the three treatment groups (P < 0.05), most significantly in the HOHS group (P < 0.01) compared with…
Read ArticleIn rats, at P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. These preclinical findings…
Read ArticleIn male Sprague-Dawley rats, hydrogen water consumption reduced wet-to-dry weight ratio, malondialdehyde and myeloperoxidase activity and decreased the concentration of TNF-α, IL-1β, and IL-6 in the lung tissues…
Read ArticleIn male Sprague-Dawley rats, as shown in Figure 6B, the Nrf2 protein level increased significantly in the CS-challenged rat lungs as compared with that in the control (p<0.01),…
Read ArticleIn rats, hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha,…
Read ArticleIn mice, hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase. These preclinical findings add evidence…
Read ArticleIn an animal model, administration of H₂-rich water attenuated the CS-induced lung damage in the SMP30-KO mice and reduced the mean linear intercept and destructive index of the…
Read ArticleIn mice, combination treatment with inhaled NO and H₂ could also significantly attenuate lung injury in polymicrobial sepsis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
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