Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
This animal study examined Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCombined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4
Many studies have shown that redox regulation is an effective therapeutic strategy for different types of cancer. We have previously demonstrated that combined treatment with dissolved hydrogen molecule (H) and platinum nanocolloid (Pt-nc) has carcinostatic effects and that increased intracellular reactive oxygen species (ROS) levels were closely associated with carcinostatic effects in Ehrlich mouse ascites tumor cells. However, it is unknown whether combined treatment-induced ROS generation can occur in human cancer cells.
Read MoreControlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis.
Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration. We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials.
Read MoreHydrogen gas represses the progression of lung cancer via down-regulating CD47.
This animal study examined Hydrogen gas represses the progression of lung cancer via down-regulating CD47. The abstract describes Mouse model. The abstract reports: In our previous study, our project group found that H2 could decrease the expression of CD47 in lung cancer A549 cells via the next-generation…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
This animal study examined Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: This study extended our original analysis of the ability of hydrogen to stimulate NLRP3 inflammasome/GSDMD activation in pyroptosis and revealed possible mechanism (s) for…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension
This animal study examined Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. The abstract describes Rat model. The abstract reports: Our findings suggest that chronic H gas inhalation may help prevent LV hypertrophy in hypertensive DS rats. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtection of oral hydrogen water as an antioxidant on pulmonary hypertension
This animal study examined Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT group were significant higher than…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
Molecular hydrogen (H) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H on lung inflammation and blood pressure. In this study, we further focused the biological effects of H on mast cells (MCs) and the parameters of the fibrotic phenotype of the local tissue microenvironment.
Read MoreHydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation
This animal study examined Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation. The abstract describes Rat model; reported duration 5 weeks. The abstract reports: We found that the systolic and diastolic blood pressure (BP) increased significantly in rats exposed to intermittent hypoxia, both of which were markedly attenuated…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats.
This animal study examined Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
This animal study examined Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats, which may be associated with its antioxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreConsumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
This uncontrolled human study examined Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
This animal study examined Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. The abstract describes Rat model. The abstract reports: Molecular hydrogen ameliorates MCT-induced PAH in rats by suppressing macrophage accumulation, reducing oxidative stress and modulating the STAT3/NFAT axis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
This animal study examined Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: The results showed that, although hydrogen inhalation had no effect on the main markers of pulmonary hypertension induced by monocrotaline injection, there was a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDaily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
This animal study examined Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. The abstract describes Rat model. The abstract reports: A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H) improves blood pressure control in end-stage kidney disease. This is an automated editorial draft based on the abstract and requires source review before publication.
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