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In male Sprague-Dawley rats, 6d ), although there were statistically significant differences in M30 CytoDeath-positive cells (0.7 ± 0.1 and 0.9 ± 0.2 positive cells/field in the Fe-HD and Fe-H₂ PD groups, respectively; p < 0.05) (Fig. These preclinical findings add evidence…
Read ArticleIn blood gases, pH, PaO 2, and BE decreased and lactate increased, but recovered to baseline after 3 h, with no difference between the HI and HI-H₂ groups…
Read ArticleIn rats, hRS reversed these changes, with the exception of HO-1 expression, which was increased further, and improved renal morphology. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn an animal model, marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). These preclinical findings add evidence supporting molecular…
Read ArticleIn an animal model, after storage of the kidney in hydrogen-free preservation solution for 1 hour before transplantation, no urine production was observed and blood flow was not…
Read ArticleIn an animal model, nineteen serum metabolites and 7 urine metabolites showed significant restoration to normal levels after hydrogen gas (H₂) treatment. These preclinical findings add evidence supporting…
Read ArticleIn mice, however, the proportion of M1-type macrophages was significantly lower and the proportion of M2-type macrophages was significantly higher in the hydrogen-rich-medium-treated LPS/IFN-γ group than in the…
Read ArticleIn male Sprague-Dawley rats, kEY FINDINGS: the researchers demonstrated that rats who inhale hydrogen gas showed improved renal function, alleviated pathological damage, oxidative stress and apoptosis in CIH…
Read ArticleIn a preliminary study of hydrogen’s protective effect in kidneys, the researchers analyzed kidney morphology and function at 24 h after I/R injury, and the researchers found similar…
Read ArticleIn contrast, treatment with HW improved allograft function, slowed the progression of CAN, reduced oxidant injury and inflammatory mediator production, and improved overall survival. These preclinical findings add…
Read ArticleIn rats, as shown in Figures 7(d) and 8(c), the expression of I κ B and IL-10 in renal tissues at 12 hours was significantly decreased after SAP…
Read ArticleIn male Sprague-Dawley rats, however, administration of HS significantly reduced the injury score. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological…
Read ArticleIn rats, all these factors were significantly improved by both doses of HRS, but the mean histologic damage score, urea, Cr, CK, ROS, 8-OH-dG, GSH-PX, IL-6, and TNF-α…
Read ArticleIn Sprague-Dawley rats, the activated pro-apoptotic kinase JNK (p-JNK) exhibited increased expression after burn injury, and the most significant elevation was observed at 72 h post burn (all…
Read ArticleIn male Sprague-Dawley rats, cytoprotective effects of the dual treatment in comparison with H₂ treatment and I-R renal injury were observed in terms of superoxide radical scavenging activity…
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