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In an animal model, the NT, H₂, and H₂ -TH groups showed a significant reduction in HR at 0 h (end of insult), whereas the TH group showed a nonsignificant reduction in HR compared with baseline. These preclinical findings add evidence supporting…
Read ArticleIn Pulmonary microvascular endothelial cells were divided into 4 groups: blank, control, oxygen (O₂), and H₂, the pH values in the O₂ (7.17 ± 0.05) and H₂ groups…
Read ArticleIn rats, hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‑stress marker MDA and expression…
Read ArticleIn mice, although treatment of diabetic mice with hydrogen water did not significantly affect blood glucose level, it significantly attenuated cardiac hypertrophy and reduced expression of atrial natriuretic…
Read ArticleIn an animal model, although the W/D ratio in the CPB group significantly increased as compared with that in the SHAM group, such an increase was also suppressed…
Read ArticleIn rats, it also decreased neutrophil infiltration, 3-nitrotyrosine level, expression of intercellular adhesion molecule 1(ICAM-1) and myeloperoxidase (MPO) activity in the area at risk zones (AAR) of rat…
Read ArticleIn a laboratory model, xIE et al: Nrf2/HO-1 PATHWAY MEDIATES H₂ GAS MYOCARDIAL PROTECTION114 8 agent CoCl2, at 400 -1,000 µM for 24 h, reduced cell viability in…
Read ArticleIn rats, finally, as a pivotal transcription factor in reactive oxygen species (ROS)-apoptosis signaling pathway, the expression and phosphorylation of p53 were significantly reduced by H₂ treatment in…
Read ArticleWhen H₂ was pressurized into the medium for 2, 4, 6, 12, 24, 36, and 48 hours, the absorbance of medium containing H₂ at 450 nm was higher…
Read ArticleIn mice, nO inhalation plus H₂ reduced the infarct size/AAR, with significant interaction between the two, reducing ROS and neutrophil infiltration, and improved the cardiac function to normal…
Read ArticleThe researchers found that both 0.3 mmol/L and 0.6 mmol/L (i.e., saturated) H₂-rich media improved cell viability and cellular apoptosis in LPS-activated HUVECs and that 0.6mmol/L (i.e., saturated)…
Read ArticleIn Sprague-Dawley rats, the purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from…
Read ArticleIn Human umbilical vein endothelial cells (HUVECs) were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for various time periods in normal or hydrogen-rich medium, however, HUVECs incubated in hydrogen-rich medium did…
Read ArticleIn a laboratory model, the OC in the hydrogen group was higher than in the control group, but the difference was not statistically significant (P = 0.0862). The…
Read ArticleIn Sprague Dawley rats, hRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cellular apoptosis and the release of MDA and LDH compared…
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