Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In an animal model, nineteen serum metabolites and 7 urine metabolites showed significant restoration to normal levels after hydrogen gas (H₂) treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn mice, however, the proportion of M1-type macrophages was significantly lower and the proportion of M2-type macrophages was significantly higher in the hydrogen-rich-medium-treated LPS/IFN-γ group than in the…
Read ArticleIn Recent studies have indicated H₂ can be used as a novel antioxidant to protect cells, decreased FtL and FtH protein expression level to 73% and 62% respectively…
Read ArticleIn mice, the renal expressions of osteopontin (OPN), CD44, monocyte chemoattractant protein-1 (MCP-1) and interleukin-10 (IL-10) were markedly increased in glyoxylate-treated mice, and H₂ significantly attenuated the increase…
Read ArticleIn rats, one day after the injection, serum levels of urea nitrogen were significantly lower in H₂ gas-inhaling CIAKI rats (17.6 ± 2.3 mg/dl) than those in control…
Read ArticleIn rats, of scores for kidney appearance showed that for 4% H₂ inhalation, morphological lesions were alleviated in about 70% rats of this group, while for 67% H₂…
Read ArticleIn Inflammation in male C57/BL6J mice or RAW264.7 cells was induced with LPS, for which hydrogen was immediately administered until samples were taken, hydrogen alleviated LPS-induced inflammatory infiltration…
Read ArticleIn mice, repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice, assessed by tail suspension…
Read ArticleIn mice, the inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to 70 or 60%, respectively. These preclinical…
Read ArticleIn mice, treatment of ovalbumin-sensitized and challenged mice with hydrogen reversed the energy metabolic pathway switch, and mitigated airway inflammation. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn participants with ISSNHL to receive either H₂ (H₂ group) or air as a placebo (control group) through inhalation combined with the administ, the hearing threshold 3 months…
Read ArticleHydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained…
Read ArticleIn mice, the ulcer size in control mice at 4 days after reperfusion was assigned a value of 100%. * P <.05; ** P <.01; *** P <.001…
Read ArticleIn rats, at 2 hours after fluid resuscitation, blood pressure remained in the normal range and metabolic acidosis was well compensated in the H₂ gas-treated rats, whereas the…
Read ArticleIn Sprague Dawley rats, both profiles of high-dose H₂ breathing reduced the size of the endometrial explants, inhibited cell proliferation, improved superoxide dismutase, glutathione peroxidase, malondialdehyde, and catalase…
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